Authors: Jane Flint, Vincent Racaniello, Glenn Rall, Theodora Hatziioannou, Anna Marie Skalka
Publisher: ASM Press (2023) · Language: English
Principles of Virology, Volume 1: Molecular Biology, 5th Edition is the definitive resource for understanding the molecular mechanisms that underlie virus structure, replication, and gene expression. Authored by leading virologists Jane Flint, Vincent Racaniello, Glenn Rall, Theodora Hatziioannou, and Anna Marie Skalka, this edition offers a comprehensive and integrative exploration of modern molecular virology.
This volume—part of the two-book Principles of Virology set—focuses on the fundamental biological processes that define viruses as unique biological entities. It examines how viruses interact with host cells, how they replicate and evolve, and how these molecular principles form the foundation for understanding viral pathogenesis and control strategies.
Understand what makes viruses distinct from other microorganisms, including their structure, classification, and evolutionary origins.
Explore the organization of viral genomes, capsids, and envelopes, and how these components determine infectivity and stability.
Learn how diverse viruses replicate their genomes and express genes using host and viral machinery.
Study how viruses manipulate cellular pathways, evade immune responses, and adapt to environmental pressures.
Analyze the molecular steps of viral entry, genome replication, assembly, and release.
Discover how modern techniques—such as cryo-EM, next-generation sequencing, and reverse genetics—have revolutionized viral research.
Incorporates recent advances in molecular virology, including SARS-CoV-2 biology and pandemic-related discoveries.
Updated coverage of emerging viruses, viral evolution, and host-pathogen interactions.
Enhanced figures, data visualizations, and concept boxes to clarify complex molecular processes.
Expanded discussions on antiviral strategies, virus-host coevolution, and synthetic virology.
Integration of current experimental methods and bioinformatics tools in viral research.
Principles of Virology has long set the standard for excellence in virology education and research. Volume 1 focuses on molecular mechanisms, providing a rigorous yet accessible foundation for understanding viral biology. The text combines scientific depth, experimental insight, and clarity of presentation, making it equally valuable to students, educators, and researchers.
This edition bridges the gap between fundamental molecular biology and modern applications, such as vaccine development, antiviral therapy, and biotechnology.
Undergraduate and Graduate Students studying virology, molecular biology, or microbiology.
Medical and Biomedical Science Students seeking a solid grounding in viral molecular mechanisms.
Researchers and Educators requiring an authoritative reference in molecular virology.
Professionals in Biotechnology and Public Health working with viral systems or therapeutics.
Structure and composition of viruses
Genome replication strategies
Gene expression and regulation
Virus entry, assembly, and release
Host–virus molecular interactions
Mutation, recombination, and evolution
Viral genetics and reverse genetics systems
Technological advances in viral study
Molecular basis of antiviral development
Principles of Virology, Volume 1: Molecular Biology, 5th Edition offers a detailed and up-to-date understanding of how viruses function at the molecular level. Through its clear explanations, cutting-edge research integration, and conceptual organization, it provides readers with a comprehensive foundation in the molecular biology of viruses.
Whether used in the classroom, laboratory, or research setting, this edition remains an indispensable reference for mastering the molecular principles that govern viral life cycles and their profound impact on health and science.