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Principles of Virology Volume 1: Molecular Biology (ASM Books) 5th Edition
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Principles of Virology Volume 1: Molecular Biology (ASM Books) 5th Edition

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Authors: Jane Flint, Vincent Racaniello, Glenn Rall, Theodora Hatziioannou, Anna Marie Skalka
Publisher: ASM Press (2023) · Language: English


Overview

Principles of Virology, Volume 1: Molecular Biology, 5th Edition is the definitive resource for understanding the molecular mechanisms that underlie virus structure, replication, and gene expression. Authored by leading virologists Jane Flint, Vincent Racaniello, Glenn Rall, Theodora Hatziioannou, and Anna Marie Skalka, this edition offers a comprehensive and integrative exploration of modern molecular virology.

This volume—part of the two-book Principles of Virology set—focuses on the fundamental biological processes that define viruses as unique biological entities. It examines how viruses interact with host cells, how they replicate and evolve, and how these molecular principles form the foundation for understanding viral pathogenesis and control strategies.


What You’ll Learn

1. The Nature of Viruses

Understand what makes viruses distinct from other microorganisms, including their structure, classification, and evolutionary origins.

2. Virus Structure and Composition

Explore the organization of viral genomes, capsids, and envelopes, and how these components determine infectivity and stability.

3. Genome Replication and Expression

Learn how diverse viruses replicate their genomes and express genes using host and viral machinery.

4. Virus–Host Interactions

Study how viruses manipulate cellular pathways, evade immune responses, and adapt to environmental pressures.

5. Molecular Mechanisms of Infection

Analyze the molecular steps of viral entry, genome replication, assembly, and release.

6. Experimental and Technological Advances

Discover how modern techniques—such as cryo-EM, next-generation sequencing, and reverse genetics—have revolutionized viral research.


What’s New in the 5th Edition

  • Incorporates recent advances in molecular virology, including SARS-CoV-2 biology and pandemic-related discoveries.

  • Updated coverage of emerging viruses, viral evolution, and host-pathogen interactions.

  • Enhanced figures, data visualizations, and concept boxes to clarify complex molecular processes.

  • Expanded discussions on antiviral strategies, virus-host coevolution, and synthetic virology.

  • Integration of current experimental methods and bioinformatics tools in viral research.


Why This Book Matters

Principles of Virology has long set the standard for excellence in virology education and research. Volume 1 focuses on molecular mechanisms, providing a rigorous yet accessible foundation for understanding viral biology. The text combines scientific depth, experimental insight, and clarity of presentation, making it equally valuable to students, educators, and researchers.

This edition bridges the gap between fundamental molecular biology and modern applications, such as vaccine development, antiviral therapy, and biotechnology.


Who Should Read This Book

  • Undergraduate and Graduate Students studying virology, molecular biology, or microbiology.

  • Medical and Biomedical Science Students seeking a solid grounding in viral molecular mechanisms.

  • Researchers and Educators requiring an authoritative reference in molecular virology.

  • Professionals in Biotechnology and Public Health working with viral systems or therapeutics.


Key Topics Covered

  • Structure and composition of viruses

  • Genome replication strategies

  • Gene expression and regulation

  • Virus entry, assembly, and release

  • Host–virus molecular interactions

  • Mutation, recombination, and evolution

  • Viral genetics and reverse genetics systems

  • Technological advances in viral study

  • Molecular basis of antiviral development


Conclusion

Principles of Virology, Volume 1: Molecular Biology, 5th Edition offers a detailed and up-to-date understanding of how viruses function at the molecular level. Through its clear explanations, cutting-edge research integration, and conceptual organization, it provides readers with a comprehensive foundation in the molecular biology of viruses.

Whether used in the classroom, laboratory, or research setting, this edition remains an indispensable reference for mastering the molecular principles that govern viral life cycles and their profound impact on health and science.

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